✦ LIBER ✦

Further evaluation of a live hepatitis A vaccine in marmosets

✍ Scribed by P. J. Provost; F. S. Banker; C. W. Wadsworth; D. L. Krah

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 538 KB
Volume: 34
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890340406

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Live, attenuated F́ hepatitis virus was studied in vivo in Saguinus labiatus marmosets for possible reversion to virulence, for possible establishment of persistent infection and for its capacity as a parenterally administered vaccine to induce immunity to oral infection. Serial transmission of the virus in S. labiatus, using infectious stool extracts for the second and third passages, produced no evidence of reversion of the F́ vaccine virus to virulence. Monitoring for live HAV in stools over a 135‐day period postinoculation of marmosets with the F′ vaccine revealed no evidence of persistent infection. Vaccinated animals were also shown to be resistant to infection on challenge by the oral route as well as by the previously demonstrated parenteral route.

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