Further developments in metal-catalysed CC bond cleavage in allylic dimethyl malonate derivatives

✍ Scribed by Hervé Bricout; Jean-François Carpentier; André Mortreux

• Book ID: 104256255
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 235 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02510-5

✦ Synopsis

The use of a catalytic amount of nickelbis (l,4-bis(diphenylphosphino)butatne) in DMF enables the activation of the C-C bond in dimethyl allylmalonate derivatives to proceed under rather smooth reaction conditions, without added nucleophile. Several examples like isomerization of substituted-allyl raalonate derivatives, racemization of chiral products, but also a synthetic application as an inverse disproportionation reaction are described.