Further development of a versatile microscale automated workstation for parallel adaptive experimentation
✍ Scribed by David G. Cork; Tohru Sugawara; Jonathan S. Lindsey; L. Andrew Corkan; Hai Du
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 228 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0895-7533
No coin nor oath required. For personal study only.
✦ Synopsis
We have further developed our microscale automated chemistry workstation for investigating the optimization of reaction conditions. The workstation includes a Cartesian robot for solvent delivery and reagent/sample handling, a 60-vessel reaction block, a UV-Vis absorption spectrometer, and vial racks for compound storage. This article describes the following hardware additions that increase the scope and versatility of the workstation: (a) an analytical high performance liquid chromatography (HPLC) instrument and accompanying hardware interface (slide rail, autosampler); (b) three reactor blocks of 20 vessels each, with independent temperature control of each reactor block between ca. 0 and 80ЊC; (c) a shaker rack for mixing, dilution, or extraction of samples; (d) a rotary valve on the dispense line for complete isolation of 4 independent solvent lines; (e) sample workup features using disposable cartridges or filters; (f) provisions for dispensing inert gas, for example, for flushing through reactors or for storing solvents and performing trans-