Further considerations on model-independent bioavailability estimation

Estimation of absorption rate constant i

Estimation of absorption rate constant in a one-compartment model with the profile of the bioavailable dose eliminated as a function of multiples of half-life

✍ P. Macheras; M. Symillides; C. Reppas 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB 👁 1 views

In a recent study, Chen and Pelsorl reevaluated the applicability of the half-life approach in the assessment of the relative extent of drug absorption for bioavailabilityl bioequivalence studies. This approach is based on the comparisons of the truncated areas under the curve (AUCs; that is, AUC, )