Further characterization of the guinea pig left atrial tension response to histamine by use of selective agonists

Use of Selective Agonists and Antagonist

Use of Selective Agonists and Antagonists to Characterize Tachykinin Receptors Mediating Airway Responsiveness in Anaesthetized Guinea-pigs

✍ L. Yuan; E. Burcher; B.S. Nail 📂 Article 📅 1994 🏛 Elsevier 🌐 English ⚖ 426 KB

SUMMARY: Tachykinins are potent bronchoconstrictors. Here we have used novel highly selective agonists and antagonists to characterize tachykinin receptors mediating bronchoconstriction and hypotension in anaesthetized, paralysed guinea-pigs. Total lung resistance \(\left(R_{L}\right)\) and dynamic