๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Further analysis of the replication bypass model for sister chromatid exchange

โœ Scribed by D. G. Stetka

Publisher
Springer
Year
1979
Tongue
English
Weight
384 KB
Volume
49
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

โœฆ Synopsis

The replication bypass model for sister chromatid exchange (SCE) proposed by Shafer is examined in detail. When applied through two cell cycles, the model predicts that potentially observable SCEs induced during one S phase will then be cancelled and rendered undetectable during the subsequent S phase. This aspect of replication bypass is inconsistent with the observation of twin SCEs in tetraploid cells. Furthermore, the model cannot account for the efficient induction of SCEs by non-cross-linking chemical agents.

๐Ÿ“œ SIMILAR VOLUMES

Replication bypass model of sister chrom
Replication bypass model of sister chromatid exchanges and implications for Bloom's Syndrome and Fanconi's anemia
โœ David A. Shafer ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer ๐ŸŒ English โš– 959 KB

A model of the sister chromatid exchange (SCE) process is outlined as a replication mechanism to bypass DNA crosslinks. The model suggests that when normal bidirectional replication advances from both sides towards a crosslink along the two opposite parental strands, the complementary parental stran

Gene Amplification by Unequal Sister Chr
Gene Amplification by Unequal Sister Chromatid Exchange: Probabilistic Modeling and Analysis of Drug Resistance Data
โœ David E. Axelrod; Keith A. Baggerly; Marek Kimmel ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 505 KB

Unequal sister chromatid exchange has been proposed as one of several possible mechanisms for gene amplification resulting in tandemly repeated sequences on chromosomes. Two requirements for testing this hypothesis are analytical observations and a mathematical model. Recently observations were repo

Analysis of the frequency and distributi
Analysis of the frequency and distribution of sister chromatid exchanges in cultured human lymphocytes
โœ Peter E. Crossen; Maximo E. Drets; Frances E. Arrighi; Dennis A. Johnston ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer ๐ŸŒ English โš– 409 KB

Lymphocytes from 20 notmal subjects (11 male and 9 female) were examined for the frequency and location of sister chromatid exchanges (SCE) by the BrdU--Giemsa method. The mean frequency of SCE was 6.37 with little significant variation. One subject had a high number of exchanges in chromosome 1 whi