Furopyridines. XIII. Reaction of 2-methylfuro[2,3-b]-, -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridines with lithium diisopropylamide
✍ Scribed by Shunsaku Shiotani
- Book ID
- 112130715
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1993
- Tongue
- English
- Weight
- 765 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
## Abstract Bromination of α‐cyanopyridine derivatives of furopyridines 1a‐d gave the 2,3‐dibromo‐2,3‐dihydro compounds 2a‐d in excellent yields. Treatment of 2a‐d with sodium hydroxide in methanol yielded compounds formed through the dehydrobromination and solvolysis of the nitrile. __N__‐Oxidatio
## Abstract Bromination of 2‐methylfuropyridines 1a‐d‐Me gave the 3‐bromo derivatives 2a‐d, while the 2‐cyano compounds 1a‐d‐CN resulted in the recovery of the starting compounds. Nitration of 1a‐d‐Me and 1a‐d‐CN did not yield the corresponding nitro derivative, except for 1‐c‐CN giving 3‐nitro der
## Abstract Bromination of 3‐bromofuro[2,3‐__b__]‐ 1a, ‐[3,2‐__b__]‐ 1b and ‐ [3,2‐__c__]pyridine 1d afforded the 2,3‐dibromo derivatives 2a, 2b and 2d, while the ‐[2,3‐__c__]‐ compound 1c did not give the dibromo derivative. Nitration of 1a‐d gave the 2‐nitro‐3‐bromo compounds 3a‐d. The __N__‐oxid