Furanosesquiterpenoids in sponges - IV: Microcionins from microciona toxystila

✍ Scribed by G. Cimino; S. De Stefano; A. Guerriero; L. Minale

• Publisher: Elsevier Science
• Year: 1975
• Tongue: French
• Weight: 227 KB
• Volume: 16
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)91319-4

✦ Synopsis

The sponges continue to yield an array of furanosesquiterpenoias. Recently we reported the occurrence of ten furanosesquiterpenes from Disidea pallescensl and three from Pleraplysilla spinifera2,3, most of them biogenetically interesting, since the resultant sesquiterpene rings were unknown. Acetone extraction of fresh specimens of the marine sponge Microciona sstila followed by ether-water partition of the residue and chromatography on AgNO, -treated silica gel (light petroleum and increasing amounts of benzene) of the ether soluble fraction has now yielded forr additional furanosesquiterpenes, microcionin-1 (1, 0.04% of the dry weightd animal), -2 (2, 0.18%), -3 (3, 0.42%) and -4 (4, 0.20%) and this report concerns with their structures. All compounds, oils homogeneous on SiO,-AgNO, t.1.c. and g.1.c. (3% SE-30 at 130") and giving positive test with Ehrlich reagent,were isomeric and analyzed for C IsH220 (accurate mass measurements). g5 l BF3-etherate h 12395