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Fungicide Activity of 5-(4-Chlorobenzylidene)-(Z)-2-dimethylamino-1,3-thiazol-4-one against Cryptococcus Neoformans

✍ Scribed by Braulio Insuasty; Alexander Gutiérrez; Jairo Quiroga; Rodrigo Abonia; Manuel Nogueras; Justo Cobo; Laura Svetaz; Marcela Raimondi; Susana Zacchino

Book ID: 101639600
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 324 KB
Volume: 343
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.200900187

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✦ Synopsis

Abstract

The present work describes the synthesis and antifungal evaluation of new 5‐arylidene‐(Z)‐2‐dimethylamino‐1,3‐thiazol‐4‐ones 4a–f, obtained by the reaction of aromatic aldehydes 1 and rhodanine 2 followed by treatment with DMF. All compounds were tested against a panel of yeasts, hialohyphomycetes, and dermatophytes using the microbroth dilution method. Compounds 4a and 4c showed antifungal activity, with compound 4a being the most active one. Compound 4a demonstrated to be fungicidal rather than fungistatic and selective activity against Cryptococcus neoformans and dermatophytes. MIC~100~, MIC~80~, and MIC~50~ of 4a were determined against a panel of clinical isolates of C. neoformans showing ranges of MICs between 2 and 16 μg/mL.

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