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Fungal and bacterial regioselective hydroxylation of pyrimidine heterocycles

✍ Scribed by Vicente Gotor; Margarita Quirós; Ramón Liz; Jordi Frigola; Rosa Fernández

Book ID
104207763
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
735 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

The bacterium Rhodococcus erythropolis is employed to hydroxylate the anxiolytic lesopitron, and this bacterium, together with Agrobacterium sp. and the fungus Beauveria bassiana, are used to extend the field of hydroxylation of heteroaromatic compounds to a series of unexplored pyrimidines. Of all the substrates investigated, only the carbamate lla is regioselectively hydroxylated by B. bassiana at the C-5 position of the pyrimidine ring; in contrast, the bacteria are able to regioselectively oxidize, when free, the C-2 and/or C-4 positions of the pyrimidine moiety of all the substrates la -12a, up to a maximum of two oxidations.

📜 SIMILAR VOLUMES

ChemInform Abstract: Fungal and Bacteria
ChemInform Abstract: Fungal and Bacterial Regioselective Hydroxylation of Pyrimidine Heterocycles.
✍ V. GOTOR; M. QUIROS; R. LIZ; J. FRIGOLA; R. FERNANDEZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

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