Using Recent Examples And Important Case Studies, The Fundamentals Of Early Clinical Drug Development: From Synthesis Design To Formulation Demonstrates The Central Role℗¡that Organic Synthesis Plays In The Early Clinical Evaluation Of Potential Drug Candidates. Reflections On Process Research Ii / Edward J.j. Grabowski -- Development And Scale-up Of A Heterocyclic Cross-coupling For The Synthesis Of 5-(2-(3-methyl-3h-imidazol-4-yl)thieno(3,2-b)pyridin-7-yl)amino-2-methyl-1h-indol / John A. Ragan -- Large-scale Enantioselective Preparation Of 2e,7e, 5s,6r, 5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic Acid, A Key Fragment For The Formal Total Synthesis Of The Anti-tumor Agent Cryptophycin 52 / James Aikins ... [et Al.] -- Efforts Toward A Commercially Viable Route And Process To The Synthesis Of Hiv Pi Gw640385x / John C. Roberts ... [et Al.] -- Development Of An Asymmetric Synthesis Of Abt-100 / Albert W. Kruger ... [et Al.] -- Asymmetric Hydrogenation: A New Route To Pregabalin / Rex Jennings ... [et Al.] -- Responsibilities Of The Process Chemist: Beyond Synthetic Organic Chemistry / Stéphane Caron -- Outsourcing: The Challenge Of Science, Speed, And Quality / Simone Andler-burzlaff, Jason Bertola, And Roger E. Marti -- Automation And The Changing Face Of Process Research In The Pharmaceutical Industry / Edward J. Delaney ... [et Al.] -- Large Scale Synthesis: An Engineering Perspective / Joseph H. Childers, Jr. -- Synthesis And Application Of Radioisotopes In Pharmaceutical Research And Development / Larry E. Weaner And David C. Hoerr -- Selection Of The Drug Form In Exploratory Development / George J. Quallich -- Strategies To Control Particle Size Of Active Pharmaceutical Ingredients / David J. Am Ende And Peter R. Rose -- Challenges In Early Formulation: Turning Drug Substance Into Drug Product / Mark H. Kleinman And Beeah Lee -- Intellectual Property And Early Development / Maria I. Shchuka. Edited By Ahmed F. Abdel-magid And Stéphane Caron. Includes Bibliographical References And Index.