𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Fundamental studies on alcohol dependence and disposition

✍ Scribed by Setsuo Komura; Tatsuya Fujimiya; Kanji Yoshimoto

Book ID
103902760
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
658 KB
Volume
80
Category
Article
ISSN
0379-0738

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✦ Synopsis

This article reviews some recent studies on alcohol preference, dependence, metabolism and pharmacokinetics which were mainly carried out in our department. The inbred strains of mice with genetically different alcohol drinking behavior and alcohol animal model treated with the neurotoxins, 6-hydroxydopamine and 5,7-dihydroxytryptamine, are useful for a behavioral and pharmacological approach to evaluate the contribution of specific neural systems to alcohol, drug dependence mechanism and alcohol drinking behavior. The relations between alcohol preference and some physiological conditions are reviewed. On the drug-alcohol interaction, some drugs containing the chemical group =CHONO,, antimony and methamphetamine are addressed. This article also deals with recent topics in the pharmacokinetics and pharmacodynamics of alcohol. The dose-dependency of the alcohol elimination rate, the first-pass metabolism during alcohol drinking, and the pharmacodynamic model for describing pulse rate reaction to plasma acetaldehyde are discussed.

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