Fundamental Immunology (4th edn) edited by W.E. Paul

✍ Scribed by Philip F Mixter

• Book ID: 104299167
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 107 KB
• Volume: 20
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(99)01533-9

✦ Synopsis

could provide a new strategy to develop an effective vaccine against HIV-1 infection.

Crystallographic analysis indicates that the binding of gp120 to both CD4 and a chemokine receptor induces conformational changes in gp41 from the native structure to the fusion-active structure. The exposed coiled coils create a fusion intermediate, in which the C-domain and N-domain are exposed 6 .

Recent studies have demonstrated that a fusion-competent vaccine with broad neutralization of HIV primary isolates is associated with these fusion intermediates 7,8 , suggesting that the C-and N-domain of gp41 in the fusion intermediates could contribute to their broad neutralization activity. In addition, the C-and N-domain of gp41 have been shown to bind a putative cellular receptor 9,10 , which might explain the protective mechanism of the C-and N-domainbased vaccine.