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Functions of the nuclear lamins

โœ Scribed by O. A. Vaughan; W. G. E. Whitfield; C. J. Hutchison

Publisher
Springer Vienna
Year
2000
Tongue
English
Weight
755 KB
Volume
211
Category
Article
ISSN
0033-183X

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## The nuclear envelope has recently become the object of intense scrutiny because it is the site of nuclear transport and is possibly involved in the organization of the interphase genome, thereby aflecting gene expression. The major structural support for the nuclear envelope is the nuclear lamina

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Cell-free extracts of Xenopus eggs were used to investigate how differing lamin sub-types are incorporated into a lamina and how lamina composition influences DNA replication. Purified recombinant human lamin A (HlaminA) was inoculated into egg extracts, which support in vitro nuclear assembly. The