Diastereoselective route to (2R,5S)- and
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Paulo H.G. Zarbin; Alfredo R.M. de Oliveira; Carlos E. Delay
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Article
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2003
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Elsevier Science
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French
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A diastereoselective approach to (2R,5S)-and (2S,5S)-2-methyl-1,6-dioxaspiro[4.5]decane 1 and 1a is described. The route starts with an alkylation reaction among the cyclopentanone N,N-dimethylhydrazone 6 and the chiral iodides (R)-3 or (S)-3, derived from the enantiomers of ethyl b-hydroxybutyrate,