Functionalized Crown Ethers as an Approach to the Enzyme Model for the Synthesis of Peptides
โ Scribed by SHIGEKI SASAKI; MITSUHIKO SHIONOYA; HISAAKI CHAKI; KENJI KOGA
- Book ID
- 118724116
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 91 KB
- Volume
- 471
- Category
- Article
- ISSN
- 0890-6564
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๐ SIMILAR VOLUMES
We have previously described the conditions by which peptide synthesis by the solid-phase fragment condensation approach can be carried out using crown ethers as non-covalent protection for the N alpha-amino group. Here we demonstrate that the procedure can be extended to large, partially protected
Herein we report an efficient method for synthesis of b-alkylated and b,b-dialkylated a-iodo enol ethers in water. Radical addition in aqueous medium of ethyl iodoacetate, iodoacetonitrile, and iodoacetamide to ynol ethers leads to a-iodo enol ethers with moderate to excellent yields and high stereo
Received in Japsn 30 Jbacernber 1977; reoeived in UK for plblio8tiofi 9 FebmW 1978) Enzymes, enormously effective catalysts for biological reactions, are known to combine with their substrates to form highly structured enzyme-substrate complexes as an essential step in their catalytic reactions. 1)
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