Functionalized 2-azabicyclo[3.3.1]nonanes. X. α,α′-annelation of 1-benzyl-2,5-piperidinedione and isolation of an azabicyclic adduct as stable hydrate

✍ Scribed by Josep Bonjoch; Josefina Quirante; Isabel Serret; Joan Bosch

• Book ID: 104229751
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 153 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)99599-6

✦ Synopsis

The reaction of the pyrrolidine enamine derived from l-benzyl-2,5_piperidinedione with acrolein afforded a 3,6,9-trifunctionalized 2-azabicyclo[3.3.1] nonane system, which could be isolated as a stable ketone hydrate.