Functionalization of the 3β-methyl group of penicillin
✍ Scribed by Jack E. Baldwin; Jeff E. Cobb; Lyndon N. Sheppard
- Book ID
- 108372361
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 1022 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
Irradiation of the nor-diterpene atractyligenin at u=254 nm in methanol gave, on one hand, the decarboxylation product, and provided, on the other hand, the transformation of the C-20 angular methyl into a methylene-carbomethoxy group.
The acid catalyzed ring expansion (1) of penicillin sulfoxide esters, 1, to deacetoxy cephalosporins, 2, has assumed added importance due to the demonstrated oral effectiveness of the broad-spectrum antibiotic, cephalexin (2). We now wish to report additional studies that further aid in elucidating
Methylene cephams are useful synthetic intermediates for the preparation of semisynthetic cephalosporin antibiotics."' A recent paper by Maki and Sake" reports on the photocyclisation of 4-heterocyclic dithioazetidinones to 3-methylene cephams. We have independently investigated similar transformati