Functionalization and synthetic application of pyridazin-3(2H)-ones

✍ Scribed by Sung-Kyu Kim; Deok-Heon Kweon; Su-Dong Cho; Young-Jin Kang; Ki-Hun Park; Sang-Gyeong Lee; Yong-Jin Yoon

• Book ID: 102343907
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2005
• Tongue: English
• Weight: 185 KB
• Volume: 42
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570420302

✦ Synopsis

Introduction.

Since the first preparation of pyridazines by Fischer, [1] major attention has been devoted to their chemistry only in the early few decades. However, pyridazin-3(2H)-ones and their fused ring derivatives have recently received much more attention to possess various biological activities [2][3][4][5] and also to use the asymmetric dihydroxylation catalysts and the ligands for metal complexes [2].

The first synthesis of 4,5-dihalopyridazin-3(2H)-ones was achieved by Bistrycki et al. [6,7].

Mono-and multihalopyridazin-3(2H)-ones are useful intermediates for the synthesis of pyridazine derivatives such as multisubstituted-pyridazin-3(2H)-ones and fused heterocycles involving pyridazin-3(2H)-one. Therefore, our research group became interested in the functionalization and the synthetic application of pyridazin-3(2H)-ones.