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Functional variations in the JWA gene are associated with increased odds of leukemias

✍ Scribed by Qun Shen; Wei-Yan Tang; Chun-Ping Li; Rui Chen; Yu-Jie Zhu; Shu Huang; Ai-Ping Li; Jian-Wei Zhou

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
151 KB
Volume
31
Category
Article
ISSN
0145-2126

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✦ Synopsis

The association between the -76G>C in the 5'-flanking region and 723T>G in JWA exon three variants were examined for risk of leukemia development in a hospital-based case-control study of 201 leukemia patients and 243 cancer-free controls in a Chinese population. Studies showed that the -76C allele was associated with significantly increased odds of leukemia but the 723G allele was correlated with marked decreased odds of leukemia. Variation in the -76C allele resulted in almost complete loss of oxidative stress stimulated transcription activities of the promoter fragment.

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