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Functional variation of HIV-1 Rev response element in a longitudinally studied cohort

✍ Scribed by Angsana Phuphuakrat; Robert M. Paris; Sorachai Nittayaphan; Suda Louisirirotchanakul; Prasert Auewarakul

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 106 KB
Volume: 75
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.20279

No coin nor oath required. For personal study only.

✦ Synopsis

We showed previously that HIV-1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV-1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4 þ count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression.

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