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Functional variant (−1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chinese population

✍ Scribed by Lan Jiang; Ping Zhou; Aining Sun; Jian Zheng; Bin Liu; Yonghe You; Chun Zhang; Depei Wu; Yifeng Zhou

Book ID
108587100
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
348 KB
Volume
102
Category
Article
ISSN
1347-9032

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## Abstract __MKK4__ (mitogen‐activated protein kinase kinase 4, NM\_003010.2), which belongs to the mitogen‐activated protein kinase pathways, possesses functions in tumorigenesis. We hypothesized the genetic variants in __MKK4__ gene may alter its functions and thus cancer risk. In current hospit