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Functional studies of two novel and two rare mutations in the 21-hydroxylase gene

✍ Scribed by M. Barbaro; L. Baldazzi; A. Balsamo; S. Lajic; T. Robins; L. Barp; P. Pirazzoli; E. Cacciari; A. Cicognani; A. Wedell


Book ID
105796414
Publisher
Springer
Year
2006
Tongue
English
Weight
477 KB
Volume
84
Category
Article
ISSN
0946-2716

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Two novel CYP21A2 missense mutations in
✍ Paola Concolino; Francesca Vendittelli; Enrica Mello; Cristiana Carelli Alinovi; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 225 KB

## Abstract Steroid 21‐hydroxylase deficiency is present in more than 90% of patients with congenital adrenal hyperplasia (CAH), an inherited metabolic disorder of adrenal steroidogenesis. Impaired enzymatic activity leads to the accumulation of metabolic intermediates (progesterone and 17‐hydroxyp