## Abstract Using comparative proteomic and genomic approaches, the authors identified eukaryotic translation initiation factor 5A (eIF5A) as an oncofetal molecule highly abundant in mouse embryonic livers and human hepatocellular carcinoma (HCC) cell lines. To evaluate the oncogenic role and progn
Functional significance of eIF5A and its hypusine modification in eukaryotes
β Scribed by M. H. Park; K. Nishimura; C. F. Zanelli; S. R. Valentini
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 318 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0939-4451
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## Abstract Eukaryotic translation initiation factor 5A (eIF5A) has a unique character: the presence of an unusual amino acid, hypusine, which is formed by postβtranslational modifications. Even before the identification of hypusination in eIF5A, the correlation between hypusine formation and prote
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