Functional Significance and Clinical Phenotype of Nontruncating Mismatch Repair Variants of MLH1
✍ Scribed by Tiina E. Raevaara; Mari K. Korhonen; Hannes Lohi; Heather Hampel; Elly Lynch; Karin E. Lönnqvist; Elke Holinski-Feder; Christian Sutter; Wendy McKinnon; Sekhar Duraisamy; Anne-Marie Gerdes; Päivi Peltomäki; Maija Kohonen-Ccorish; Elisabeth Mangold; Finlay MacRae; Marc Greenblatt; Albert de la Chapelle; Minna Nyström
- Book ID
- 119758641
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 553 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The hereditary colon and endometrium cancer predisposition Lynch Syndrome (also called HNPCC) is caused by a germ-line mutation in one of the DNA mismatch repair (MMR) genes. A significant fraction of the gene alterations detected in suspected Lynch Syndrome patients is comprised of amino acid subst
## Communicated by Marc Greenblatt Lynch syndrome, also known as hereditary nonpolyposis colon cancer (HNPCC), is the most common known genetic syndrome for colorectal cancer (CRC). MLH1/MSH2 mutations underlie approximately 90% of Lynch syndrome families. A total of 24% of these mutations are mis