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Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

โœ Scribed by Shinozaki, Tomomi; Nota, Ayumi; Taya, Yoichi; Okamoto, Koji


Book ID
110068257
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
407 KB
Volume
22
Category
Article
ISSN
0950-9232

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Inactivation of wild-type p53 during gastric carcinogenesis is usually caused by mutations within exons 5-8 of the p53 gene leading to mutated, usually immunohistochemically detectable p53 proteins. However, functional inactivation of wild-type p53, mimicking mutational inactivation, may also result