## Abstract Our previous work has shown that a number of sphingolipid metabolites including sphingosine, sphinganine, and other longβchain bases potently induced apoptosis in human hepatoma cells. In this study, we examined the possibility that sphingosine may trigger apoptosis in human hepatoma ce
β¦ LIBER β¦
Functional Role of Caspases in Sphingosine-Induced Apoptosis in Human Hepatoma Cells
β Scribed by Hui-Chiu Chang; Chin Hsu; Hseng-Kuang Hsu; Rei-Cheng Yang
- Book ID
- 111741479
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 234 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1521-6543
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## Abstract ## Background The caspaseβ3 gene is expressed at significantly lower levels in human hepatocellular carcinomas than in normal hepatocytes. Gene transfer technologies offer the possibility to restore caspaseβ3 gene expression. We explored the interest for cancer gene therapy of a consti