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Functional replacement of a protein-induced bend in a DNA recombination site

✍ Scribed by Goodman, Steven D.; Nash, Howard A.


Book ID
109761159
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
469 KB
Volume
341
Category
Article
ISSN
0028-0836

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## Abstract (+)‐CC ‐1065 is biologically potent DNA‐reactive antitumor antibiotic produced by __Streptomyces zelensis__. This antibiotic covalently modifies DNA by alkylation of N‐3 of a adenine in the minor groove. As a Structural consequence of covalent modification of DNA, the helix axis id bent