✦ LIBER ✦

Functional properties of regenerating skeletal muscle following LIF administration

✍ Scribed by Paul Gregorevic; Alan Hayes; Gordon S. Lynch; David A. Williams

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 90 KB
Volume: 23
Category: Article
ISSN: 0148-639X
DOI: 10.1002/1097-4598(200010)23:10<1586::aid-mus17>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

tested the hypothesis that periodic systemic administration of the myogenic cytokine leukemia inhibitory factor (LIF) enhances the functional recovery of regenerating skeletal muscle following bupivacaineinduced degeneration. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post-injury. The results do not support exogenous administration of LIF as a treatment for acute muscle injury, but a more frequent dosing regimen should be tested.