Functional NBS1 polymorphism is associat
โ
Jian Zheng; Chun Zhang; Lan Jiang; Yonghe You; Yuehui Liu; Jiachun Lu; Yifeng Zh
๐
Article
๐
2011
๐
John Wiley and Sons
๐
English
โ 634 KB
As a component of the MRN (MRE11/RAD50/NBS1) complex, NBS1 plays an important role in cellular response to DNA damage and the maintenance of chromosomal integrity. The NBS1 E185Q polymorphism (8360G>C, rs1805794) has been frequently studied in some cancers with discordant results, but its associatio