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Functional maturation of adult-generated granule cells

✍ Scribed by Linda S. Overstreet-Wadiche; Gary L. Westbrook

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
454 KB
Volume
16
Category
Article
ISSN
1050-9631

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✦ Synopsis

Abstract

The excitability and connectivity of adult‐generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity‐dependent regulation. Β© 2006 Wiley‐Liss, Inc.

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