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Functional involvement of cerebral cortex in duchenne muscular dystrophy

✍ Scribed by Vincenzo Di Lazzaro; Domenico Restuccia; Serenella Servidei; Raffaele Nardone; Antonio Oliviero; Paolo Profice; Fortunato Mangiola; Pietro Tonali; John C. Rothwell


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
75 KB
Volume
21
Category
Article
ISSN
0148-639X

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✦ Synopsis


Transcranial stimulation was performed in 4 patients with Duchenne muscular dystrophy and 4 control subjects. The patients' central motor conduction time was normal. The threshold for evoking electromyographic responses using electrical anodal stimulation was the same in both groups, but the threshold for stimulation with a circular magnetic coil at the vertex was higher in the patients. This is compatible with reduced cortical excitability that may be related to the deficiency of brain synaptic dystrophin.


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