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Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia

✍ Scribed by Alister C. Ward; Judith Gits; Fidel Majeed; Andrew A. Aprikyan; Rowena S. Lewis; Lynda A. O’Sullivan; Melvin Freedman; Sarah Shigdar; Ivo P. Touw; David C. Dale; Yigal Dror


Book ID
108675836
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
192 KB
Volume
142
Category
Article
ISSN
0007-1048

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The use of granulocyte colony-stimulating factor (G-CSF) after chemotherapy for acute myeloblastic leukemia (AML) has been reported. However, there is a drawback in that G-CSF may stimulate the proliferation of AML progenitors. To determine the parameter(s) indicative of responsiveness of AML blasts