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Functional integrity of the SH1 site in myosin from hypertrophied myocardium

โœ Scribed by Larry L. Thomas; Norman R. Alpert


Book ID
115734658
Publisher
Elsevier Science
Year
1977
Weight
534 KB
Volume
481
Category
Article
ISSN
0005-2744

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A partial clone of caldesmon, coding for the C-terminal 288 amino acids, was isolated from a human fetal liver cDNA library and sequenced. Expression of the clone in Escherichia coli produced a peptide called H1 (M r 32 549), which inhibited tropomyosin-enhanced actomyosin Mg2+-ATPase activity by 90