Functional integrity of hepatocyte canalicular membrane transport of taurocholate and bilirubin diglucuronide in eisai hyperbilirubinuria rats

PRIMARY ACTIVE TRANSPORT OF PRAVASTATIN

PRIMARY ACTIVE TRANSPORT OF PRAVASTATIN ACROSS THE LIVER CANALICULAR MEMBRANE IN NORMAL AND MUTANT EISAI HYPERBILIRUBINEMIC RATS

✍ Masayo Yamazaki; Kazuo Kobayashi; Yuichi Sugiyama 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 845 KB

We have previously demonstrated that the HMG-CoA reductase inhibitor pravastatin is efficiently taken up by the liver via the 'multispecific anion transporter' in an active manner.3 To further examine the fate of pravastatin within the liver, its biliary excretion was studied in a single-pass liver

PRIMARY ACTIVE TRANSPORT OF PROVASTATIN

PRIMARY ACTIVE TRANSPORT OF PROVASTATIN ACROSS THE LIVER CANALICULAR MEMBRANE IN NORMAL AND MUTANT EISAI HYPERBILIRUBINAEMIC RATS

✍ Masayo Yamazaki; Kazuo Kobayashi; Yuichi Sugiyama 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 855 KB

We have previously demonstrated that the HMG-CoA reductase inhibitor pravastatin is efficiently taken up by the liver via the 'multispecific anion transporter' in an active manner.3 To further examine the fate of pravastatin within the liver, its biliary excretion was studied in a single-pass liver

The effects of cryopreservation on membr

The effects of cryopreservation on membrane integrity, membrane transport, and protein synthesis in rat hepatocytes

✍ Robert De Loecker; Barry J. Fuller; Jacques Gruwez; William De Loecker 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 822 KB

Immunogold qantification of the canalicu

Immunogold qantification of the canalicular bile salt transporting protein (cBSTP) in normal and bile duct ligated rat hepatocyte plasma membranes

✍ Landmann, L.; Meier, P.J.; Bianchi, L. 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 68 KB

S-adenosyl-L-methionine prevents disrupt

S-adenosyl-L-methionine prevents disruption of canalicular function and pericanalicular cytoskeleton integrity caused by cyclosporin A in isolated rat hepatocyte couplets

✍ I D Roman; G D Johnson; R Coleman 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB

Isolated rat hepatocyte couplets were used to study the effect of S-adenosyl-L methionine (SAMe) treatment on disruption of canalicular function caused by cyclosporin A (CyA). Canalicular function was assessed by counting the percentage of couplets that were able to accumulate the fluorescent cholep

S-adenosyl-L-methionine prevents disrupt

S-adenosyl-L-methionine prevents disruption of canalicular function and pericanalicular cytoskeleton integrity caused by cyclosporin A in isolated rat hepatocyte couplets

✍ ID Roman; GD Johnson; R Coleman 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB