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Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins

✍ Scribed by Jong-Sup Park; Eun-Joo Kim; Jung-Young Lee; Hong-Sig Sin; Sung-Eun Namkoong; Soo-Jong Um

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
124 KB
Volume
91
Category
Article
ISSN
0020-7136

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The oncogenic human papillomaviruses (HPVs) are able to efficiently target p53 for degradation by the ubiquitin pathway. We previously demonstrated inefficient HPV E6-mediated degradation and resulting high steady-state levels of p53 in cell hybrids between a peripheral neuroepithelioma cell line an