Functional imaging of neuroendocrine tumors with combined PET/CT using 68Ga-DOTATATE (DOTA-DPhe1,Tyr3-octreotate) and 18F-FDG
✍ Scribed by Irfan Kayani; Jamshed B. Bomanji; Ashley Groves; Gerard Conway; Sveto Gacinovic; Thida Win; John Dickson; Martyn Caplin; Peter Joseph Ell
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 252 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Abstract
BACKGROUND.
The aim was to assess the relevant distribution of the novel PET tracer ^68^Ga‐DOTATATE in neuroendocrine tumors (NETs) with combined positron emission tomography / computed tomography (PET/CT) and compare its performance with that of ^18^F‐FDG PET/CT.
METHODS.
The imaging findings with ^68^Ga‐DOTATATE and ^18^F‐FDG on 38 consecutive patients with a diagnosis of primary or recurrent NET were compared and correlated with tumor grade on histology based on ki67 and mitotic index.
RESULTS.
The sensitivity of ^68^Ga‐DOTATATE PET/CT was 82% (31 of 38) and that of ^18^F‐FDG PET/CT was 66% (25 of 38). The sensitivity of combined ^68^Ga‐DOTATATE and ^18^F‐FDG PET/CT was 92% (35 of 38). There was greater uptake of ^68^Ga‐DOTATATE than ^18^F‐FDG in low‐grade NET (median SUV 29 vs 2.9, P < .001). In high‐grade NET there was higher uptake of ^18^F‐FDG over ^68^Ga‐DOTATATE (median SUV 11.7 vs 4.4, P = .03). There was a significant correlation with predominant tumor uptake of ^68^Ga‐DOTATATE or ^18^F‐FDG and tumor grade on histology (P < .0001).
CONCLUSIONS.
^68^Ga‐DOTATATE PET/CT is a useful novel imaging modality for NETs and is superior to ^18^F‐FDG for imaging well‐differentiated NET. Functional imaging with both ^68^Ga‐DOTATATE and ^18^F‐FDG has potential for a more comprehensive tumor assessment in intermediate‐ and high‐grade tumors. Cancer 2008. ©2008 American Cancer Society.