Functional Imaging in Oncology: Biophysical Basis and Technical Approaches - Volume 1

✍ Scribed by José L. Vercher-Conejero MD, Zhenghong Lee BS, MS, PhD, Pablo R. Ros MD, MPH, PhD (auth.), Antonio Luna, Joan C. Vilanova, L. Celso Hygino da Cruz Jr., Santiago E. Rossi (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2014
• Tongue: English
• Leaves: 557
• Edition: 1
• Category: Library

✦ Synopsis

In the new era of functional and molecular imaging, both currently available imaging biomarkers and biomarkers under development are expected to lead to major changes in the management of oncological patients. This well-illustrated two-volume book is a practical manual on the various imaging techniques capable of delivering functional information on cancer, including preclinical and clinical imaging techniques, based on US, CT, MRI, PET and hybrid modalities. This first volume explains the biophysical basis for these functional imaging techniques and describes the techniques themselves. Detailed information is provided on the imaging of cancer hallmarks, including angiogenesis, tumor metabolism, and hypoxia. The techniques and their roles are then discussed individually, covering the full range of modalities in clinical use as well as new molecular and functional techniques. The value of a multiparametric approach is also carefully considered.

✦ Table of Contents

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Cancer Biology: What’s Important for Imaging....Pages 3-28
Imaging Biomarkers and Surrogate Endpoints in Oncology Clinical Trials....Pages 29-42
Role of Molecular Imaging in the Era of Personalized Medicine: A Review....Pages 43-58
Radiotherapy and Imaging....Pages 59-76
New Therapies and Functional-Molecular Imaging....Pages 77-96
Medical Image Computing for Oncology: Review and Clinical Examples....Pages 97-124
Front Matter....Pages 125-125
Imaging Angiogenesis....Pages 127-146
Imaging of Tumor Metabolism: MR Spectroscopy....Pages 147-180
Imaging of Tumour Metabolism: 18-FDG PET....Pages 181-211
Imaging of Tumor Metabolism: PET with Other Metabolites....Pages 213-239
Current Clinical Imaging of Hypoxia with PET and Future Perspectives....Pages 241-268
MRI Hypoxia Measurements....Pages 269-289
Front Matter....Pages 291-291
Overview of Functional MR, CT, and US Imaging Techniques in Clinical Use....Pages 293-306
Diffusion-Weighted MR Imaging....Pages 307-324
Perfusion CT: Principles, Technical Aspects and Applications in Oncology....Pages 325-340
Perfusion Imaging by Magnetic Resonance....Pages 341-376
DCE-US: Evaluation of Angiogenesis....Pages 377-388
Spectroscopy of Cancer....Pages 389-409
Hybrid Imaging: PET-CT and PET-MRI....Pages 411-430
Dual-Energy and Spectral Energy Computed Tomography: Oncological Body Applications in Clinical Use....Pages 431-458
Front Matter....Pages 291-291
US Elastography: Applications in Tumors....Pages 459-488
Front Matter....Pages 489-489
New Molecular and Functional Imaging Techniques....Pages 491-522
Multiparametric Imaging....Pages 523-536
Back Matter....Pages 537-549

✦ Subjects

Imaging / Radiology; Oncology; Diagnostic Radiology