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Functional identification of genes causing estrogen independence of human breast cancer cells

โœ Scribed by Ton van Agthoven; Jos Veldscholte; Marcel Smid; Thecla L. A. van Agthoven; Lilian Vreede; Marieke Broertjes; Ingrid de Vries; Danielle de Jong; Roya Sarwari; Lambert C. J. Dorssers


Book ID
106378145
Publisher
Springer US
Year
2008
Tongue
English
Weight
307 KB
Volume
114
Category
Article
ISSN
0167-6806

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โœ Lambert C.J. Dorssers; Jos Veldscholte ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 177 KB ๐Ÿ‘ 2 views

Development of anti-estrogen resistance limits the benefit of endocrine therapy of breast cancer. The mechanistic basis for resistance to the anti-estrogen tamoxifen may involve (epi)genetic alterations within tumor cells. We have initiated a random search for genes allowing estrogen-dependent ZR-75