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Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells

โœ Scribed by Magdalena Dabrowska; Marek Skoneczny; Wojciech Rode

Book ID
107693957
Publisher
S. Karger AG
Year
2011
Tongue
English
Weight
321 KB
Volume
32
Category
Article
ISSN
1010-4283

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## Abstract Validation of targets for cancer drug discovery requires robust experimental models. Systems based on inducible gene expression are well suited to this purpose but are difficult to establish in several epithelial cell types. Using the recently discovered transcriptional transactivator (