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Functional expression of voltage-gated sodium channels Nav1.5 in human breast caner cell line MDA-MB-231

✍ Scribed by Rui Gao; Jing Wang; Yi Shen; Ming Lei; Zehua Wang

Book ID
107405885
Publisher
Springer-Verlag
Year
2009
Tongue
Chinese
Weight
677 KB
Volume
29
Category
Article
ISSN
0510-9752

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## Abstract External (but not internal) application of β‐estradiol (E2) increased the current amplitude of voltage‐gated Na^+^ channels (VGSCs) in MDA‐MB‐231 human breast cancer (BCa) cells. The G‐protein activator GTP‐γ‐S, by itself, also increased the VGSC current whilst the G‐protein inhibitor G