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Functional evidence for a telomerase repressor gene on human chromosome 10p15.1

โœ Scribed by Nishimoto, Arata; Miura, Norimasa; Horikawa, Izumi; Kugoh, Hiroyuki; Murakami, Yoshinori; Hirohashi, Setsuo; Kawasaki, Hironaka; Gazdar, Adi F; Shay, Jerry W; Barrett, J Carl

Book ID
110064461
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
373 KB
Volume
20
Category
Article
ISSN
0950-9232

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Telomeres, which are the repeated sequences located on both ends of chromosomes in eukaryotes, are known to shorten with each cell division, and their eventual loss is thought to result in cellular senescence. Unlike normal somatic cells, most tumor cells show activation of telomerase, a ribonucleop