Functional effect of point mutations in the α-folate receptor gene of CABA I ovarian carcinoma cells

Loss of HNF1α function in human renal ce

Loss of HNF1α function in human renal cell carcinoma: Frequent mutations in the VHL gene but not the HNF1α gene

✍ Ira Lemm; Anja Lingott; Elke Pogge v. Strandmann; Christiane Zoidl; Michael P. B 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB 👁 1 views

Human renal cell carcinoma (RCC) is a common malignant disease of the kidney characterized by dedifferentiation of renal epithelial cells. Our previous experiments showed that most RCCs have a loss of function of the tissue-specific transcription factor hepatocyte nuclear factor (HNF) 1α. Detailed a