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Functional dichotomy in the CD4+T cell response to Schistosoma mansoni

✍ Scribed by Edward J. Pearce; Alan Sher

Book ID
115900290
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
608 KB
Volume
73
Category
Article
ISSN
0014-4894

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CD4 + and CD8 + T cells can be divided based on the cytokines that they secrete into type 1 (Th1, Tc1) and type 2 (Th2, Tc2) subsets. Schistosoma mansoni infection in mice is characterized by a type 2-dominated response. We have used intracellular cytokine staining to demonstrate dramatic changes in