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Functional deficits resulting from laser-induced damage in the rat retina

✍ Scribed by Gil Ben-Shlomo; Mark Belokopytov; Mordechai Rosner; Galina Dubinsky; Michael Belkin; Yoram Epstein; Ron Ofri

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
147 KB
Volume
38
Category
Article
ISSN
0196-8092

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✦ Synopsis

Abstract

Background and Objectives

To determine the threshold for electrophysiological detection of functional changes after laser photocoagulation in rats, and to correlate the functional damage with retinal morphology.

Study Design/Materials and Methods

Argon‐laser lesions, covering a quarter or half of the retina, were produced in the right eyes of 25 rats. Eyes were evaluated by flash electroretinography (ERG) and histologically at 3, 21, and 60 days after lasering.

Results

Lasering of half the retina, but not of a quarter, produced a significant decrease in signals at all time points. Some functional recovery was evident 60 days after injury, and was consistent with concurrent morphological healing.

Conclusions

In rats, lasering of half the retina, but not a quarter, leads to significant deficits in outer retinal functions over a 2‐month period. Thereafter some recovery occurs, presumably as a result of migration of photoreceptors from undamaged areas and their retinal remodeling. © 2006 Wiley‐Liss, Inc.

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