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Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study

✍ Scribed by Wallace, Alison M ;Mercer, Becky A ;He, Jianqing ;Foronjy, Robert F ;Accili, Domenico ;Sandford, Andrew J ;Paré, Peter D ;D’Armiento, Jeanine M

Book ID: 119893783
Publisher: BMJ
Year: 2012
Tongue: English
Weight: 237 KB
Volume: 13
Category: Article
ISSN: 2052-4439
DOI: 10.1186/1465-9921-13-79

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## Abstract Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single guanine insertion polymorphism (2G) in the __MMP1__ promoter sequence at −1,607 creates an Ets binding site and thus results in enhancing transcriptional activity. This study aimed t