Functional characterization of the human prion protein promoter in neuronal and endothelial cells
β Scribed by H. Funke-Kaiser; S. Theis; T. Behrouzi; A. Thomas; K. Scheuch; F. Zollmann; M. Paterka; M. Paul; H.-D. Orzechowski
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 98 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0946-2716
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A synthetic peptide corresponding to the 106β126 amyloidogenic region of the cellular human prion protein (PrP^c^) is useful for in vitro study of prionβinduced neuronal cell death. The aim of the present work was to examine the implication of the cellular prion protein in the toxicity
Altered proteolysis of the amyloid precursor protein (APP) may play an important role in Alzheimer disease (AD). To better understand the role of mutant APP in the pathogenesis of the disease, we stably overexpressed the mutant APP717F approximately twofold vs. the endogenous wild-type gene in sever