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Functional Characterization of the Human Multidrug Transporter, ABCG2, Expressed in Insect Cells

✍ Scribed by Csilla Özvegy; Thomas Litman; Gergely Szakács; Zoltán Nagy; Susan Bates; András Váradi; Balázs Sarkadi

Book ID
115588194
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
109 KB
Volume
285
Category
Article
ISSN
0006-291X

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✍ Rudolf Arlanov; Andrew Porter; Dennis Strand; Rachel Brough; Darja Karpova; Rein 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 596 KB

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is involved in the efflux of endogenous and xenobiotic substrates, including several anticancer and antiviral drugs. The functional consequences of ABCC2 protein variants remain inconsistent, which may be due to shortcomings of the in vitro