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Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna

✍ Scribed by Jing Li; Marco J. van Belkum; John C. Vederas


Book ID
116318490
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
693 KB
Volume
20
Category
Article
ISSN
0968-0896

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Hyoscyamine 6b-hydroxylase (H6H; EC 1. 14.11.11), an important enzyme in the biosynthesis of tropane alkaloids, catalyzes the hydroxylation of hyoscyamine to give 6b-hydroxyhyoscyamine and its epoxidation in the biosynthetic pathway leading to scopolamine. Datura metel produces scopolamine as the pr