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Functional Characterization of Mutations in Kir4.1 (KCNJ10) Associated with the SeSAME Syndrome

✍ Scribed by Sala-Rabanal, Monica; Eaton, Misty J.; Nichols, Colin G.


Book ID
122285873
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
44 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract Mutations in the human Kir4.1 potassium channel gene (__KCNJ10__) are associated with epilepsy. Using a mouse model with glia‐specific deletion of __Kcnj10__, we have explored the mechanistic underpinning of the epilepsy phenotype. The gene deletion was shown to delay K^+^ clearance aft